Neurobiology of trigeminal pain
Research axis 3: Therapeutic strategies for orofacial pain relief
Our goal: developing and evaluating novel therapeutic approaches, both in the clinic and in preclinical models.
Ongoing projects
- Neurosteroids and neuropeptides as therapeutic targets (led by Dr G. Gazzo)
- Botulinum toxin for trigeminal pain (co-led by Pr N. Moreau & Pr Y. Boucher)
- Topical therapies (co-led by Pr N. Moreau & Pr Y. Boucher)
- Non-pharmacological interventions (led by Pr V. Descroix)
Recent publications
- Lebel A., Stambouli I., & Boucher Y. (2026). Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post-Traumatic Trigeminal Neuropathic Pain: A Real-World Evidence Study. Journal of Oral Rehabilitation: 1-12. https://doi.org/10.1111/joor.70209
- Lebel A., Da Silva Vieira D., & Boucher Y. (2024). Topical amitriptyline in burning mouth syndrome: A retrospective real-world evidence study. Headache. 2024; 64: 1167-1173. https://doi.org/10.1111/head.14818
- Moreau N., Korai SA., Papa M., Sepe G., Panetsos F., & Cirillo G. (2024). Peripheral and central neurobiological effects of botulinum toxin A (BoNT/A) in neuropathic pain: a systematic review. Pain, 165(8), 1674–1688. https://doi.org/10.1097/j.pain.0000000000003204
- Descroix V. (2020). Medical hypnosis and surgery, towards a new hermeneutic of care. J Oral Med Oral Surg, 26(4). https://doi.org/10.1051/mbcb/2020059
Read more about the two other research axes of the group: